Alkaloids are a class of naturally-occurring organic compounds that contain at least one nitrogen atom.
They are primarily found in plants, but can also be found in certain types of fungi and bacteria. In plants they appear to
play a variety of roles, including deterring herbivores and inhibiting the growth of competing plants.
Structurally, alkaloids are quite diverse. They typically have complex, ring-shaped structures, but can vary greatly in
size and shape. The chemical behavior of alkaloids is largely determined by the structure of the molecule, which includes one or more nitrogen atoms.
Alkaloids are well known for their physiological effects on humans and other animals. Many alkaloids have
pharmacological effects and are used medicinally. For instance, they can act as stimulants, narcotics, or poisons.
Some alkaloids are also used recreationally because of their psychoactive effects.
Listed below are a few examples of alkaloids and their effects:
Morphine
- Found in opium poppies, morphine is a powerful pain reliever used in medicine.
Caffeine
- Found in coffee, tea, and cacao, caffeine is a stimulant that reduces fatigue and increases alertness.
Nicotine
- Found in tobacco, nicotine is a potent parasympathomimetic stimulant that contributes to the addictive quality of tobacco products.
Atropine
- Found in deadly nightshade, atropine is used in medicine to dilate the pupils during eye exams, among other uses.
It is also a powerful poison.
Quinine
- Found in the bark of the cinchona tree, quinine was the first effective treatment for malaria.
Cocaine
- Found in coca leaves, cocaine is a powerful stimulant that is often used recreationally for its psychoactive effects.
Examples of some common alkaloids found in bark are provided below:
Quinine
- This alkaloid, found in the bark of the cinchona tree, was the first effective treatment for malaria.
It is also used as a flavoring in tonic water.
Yohimbine - Found in the bark of the Yohimbe tree, native to Africa,
yohimbine is used for its stimulant and aphrodisiac effects.
Berberine - This alkaloid is found in the bark of the cork tree and the Oregon grape tree.
It has been studied for its potential benefits in regulating blood sugar and cholesterol levels.
Akuammicine - Found in the bark of the Picralima nitida tree
(also known as the Akuamma tree), akuammicine has analgesic properties.
Taxine - This is a group of alkaloids found in the bark (and other parts)
of yew trees. Taxine alkaloids are highly toxic and can cause serious cardiac effects.
Camptothecin - Found in the bark of the Camptotheca acuminata tree,
also known as the "happy tree", camptothecin has demonstrated anti-cancer properties and is used as a chemotherapeutic agent.
Examples of some common alkaloids found in roots are provided below:
Atropine
- Found in the roots of plants in the nightshade family, such as Atropa belladonna (deadly nightshade).
It has various medical applications, including as a treatment for certain types of poisonings and to dilate the pupils during eye exams.
Reserpine - This alkaloid is found in the roots of Rauwolfia serpentina
and other Rauwolfia species. It has been used in traditional medicines and also has modern medical uses, such as in the
treatment of high blood pressure and some psychiatric disorders.
Berberine - Found in the roots of plants like goldenseal and barberry,
berberine has shown potential benefits for diabetes, cholesterol regulation, and other health conditions.
Morphine - This potent opiate is found in the latex sap of the opium poppy's
root system. It is used extensively in medicine for pain relief.
Strychnine - Found in the roots of the Strychnos nux-vomica tree,
strychnine is a potent poison that was formerly used as a pesticide.
Vincristine and Vinblastine - These alkaloids are found in the roots
of the Madagascar periwinkle (Catharanthus roseus). They are used in chemotherapy due to their ability to inhibit cell division.
Examples of some alkaloids found in seeds are listed below:
Morphine and Codeine - These alkaloids are found in the seed pods
of the opium poppy (Papaver somniferum). Both are potent analgesics and are used in medicine for pain relief.
Nicotine - This alkaloid is found in the seeds (as well as the leaves)
of the tobacco plant (Nicotiana tabacum and related species).
Strychnine - Found in the seeds of the Strychnos nux-vomica tree. It
is a potent neurotoxin and can be lethal in high doses.
Caffeine - Present in the seeds of several plants, including coffee
(Coffea spp.), cacao (Theobroma cacao), and tea (Camellia sinensis). Caffeine is a stimulant and is the most widely consumed psychoactive
substance in the world.
Quinine - The seeds and bark of the Cinchona tree contain quinine. It
has antimalarial properties and was historically the primary treatment for malaria.
The extraction process, including the solvents and methods used, can influence the concentration and types of alkaloids present in the final extract.
It is often the case that a balance needs to be found between fully-extracting all alkaloids while also ensuring that the compounds that are
obtained are of a high quality and not degraded.
At Celignis we have extensive experience in the design and optimisation of extraction protocols for a wide variety of chemical constituents from
many different biomass types. If needed we can also work on processes to separate and purify the target compounds.
Click here to read more about Celignis's Bioprocess Development Services for the extraction of
chemicals from biomass.
Celignis will be presenting their outputs from the first 12-months of the project
Celignis's Oscar and Fernando are today attending the 12-month review meeting of our CBE-JU research project MANUREFINERY. The event is taking place at the facility of project partner ENCO in Naples, Italy.
MANUREFINERY, entitled "Smart modular mobile biorefining of manure to zero-waste maximising resource recovery for feed and fertiliser bioingredients in rural areas" is one of the 7 ongoing CBE-JU projects that Celignis is currently involved in. Click here to read more about these projects.
Today we welcomed our partners from the EnXylaScope project to Limerick for the final in-person meeting of the project. The event is being held at the Limerick Strand Hotel and will include a tour of Celignis's Bioprocess and Analytical facilities.
EnXylaScope has been a hugely successful project, leading to multiple innovations in enzyme discovery and biomass processing, with Celignis making impactful developments in technologies for xylan extraction and modification. The project's success has led to a number of follow-on projects (BIONEER and PROMOFER) that involve demonstration of these technologies at higher TRL levels.
Lalitha Presents our EnXylaScope Work at EUBCE 2025
Event takes place in Valencia Spain
Lalitha is today presenting the outputs of our EnXylaScope project at the 34th European Biomass Conference & Exhibition (EUBCE) which is being held in Valencia, Spain.
The presentation, entitled "EnXylaScope: Unleashing xylan's potential with enzymes for a scope of consumer products", will provide a wide-ranging overview of the project which is now in its 4th year.
Today we registered sample number 50,000 on our internal LIMS system. Over the years we have analysed every kind of biomass sample imagineable and we look forward to achieving further milestones in the future as we continue to grow and expand our operations.
Will play a key role as our "Mechanical Engineer for Scaled-up Bioprocesses"
Today the Celignis family welcomed Dileep Raveendran-Nair to the fold. Dileep is a Mechanical Engineer with over 11 years of hands-on experience in biofuel, biochar, and bioproduct process engineering. His career has focused on the operation, maintenance, and optimization of large-scale bioprocess and bioenergy systems, integrating engineering precision with biotechnological innovation to advance sustainable industrial application.
At Celignis he will play a key-role ("Mechanical Engineer for Scaled-up Bioprocesses") in the development of our bioprocessing capabilities as we increase the Technology Readiness Levels (TRL) of our bioprocessing facility to TRL7 and cubic-metre reactors.
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